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KMID : 0370219760200020076
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Yakhak Hoeji
1976 Volume.20 No. 2 p.76 ~ p.82
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The Degradation of Indomethacin in Aqueous Solution
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전인구/Jeon IK
이민화/우종학/Lee MW/Woo CH
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Abstract
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The base-catalyzed hydrolysis of indomethacin over a range of pH 8.2 to 10.0 was investigated, according to the first order kinetic equation. The energy of activation for the reaction was calculated 20.18kcal/mole from the Arrhenius plot. And the optimal pH of indomethacin in aqueous solution was estimated as pH 4.93 by the extrapolation of the log k-pH profiles in strong acidic and alkaline regions. And the influences of alkaline earth metals, heavy metals and some other compounds on the degradation of indomethacin were observed with no effect.
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